Benhabbouche S, Crola da Silva C, Abrial M, Ferrera R
Lyon University, INSERM UMR 1060 GARMEN, Université Lyon 1, Lyon F-69008, France.
Ann Fr Anesth Reanim. 2011 May;30 Suppl 1:S2-16. doi: 10.1016/S0750-7658(11)70002-8.
The myocardial infarction represents a major cause of mortality. The deleterious phenomena arising during the ischaemia and the reperfusion of the myocardium are studied for more than 40 years. We thought for a long time that the ischaemia was the harmful stage, at the origin of the decrease of the energy stores, the dysregulation of the ionic homeostasis and the metabolic deregulation. We know now that the reperfusion itself is also a source of noxious effects (calcium overload, free radicals production, mitochondrion alteration). To combat these deleterious processes, two maneuvers demonstrated their efficiency by protecting the ischemic myocardium : it is the preconditioning and the postconditionning.
心肌梗死是主要的死亡原因。心肌缺血和再灌注过程中出现的有害现象已被研究了40多年。长期以来我们一直认为缺血是有害阶段，是能量储备减少、离子稳态失调和代谢紊乱的根源。现在我们知道，再灌注本身也是有害影响的来源（钙超载、自由基产生、线粒体改变）。为对抗这些有害过程，两种方法已通过保护缺血心肌证明了其有效性：即预处理和后处理。
