8,12;8,20-环氧-8,14-孕甾烷糖苷类化合物从 Asclepias tuberosa 的根和他们对增殖的影响人的皮肤成纤维细胞。
8,12;8,20-diepoxy-8,14-secopregnane glycosides from roots of Asclepias tuberosa and their effect on proliferation of human skin fibroblasts.
机构信息
Institute for Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
出版信息
Phytochemistry. 2011 Oct;72(14-15):1865-75. doi: 10.1016/j.phytochem.2011.05.012. Epub 2011 Jun 22.
A pregnane glycoside fraction from the roots of Asclepias tuberosa L. caused normal human skin fibroblasts to proliferate. This fraction contained 21 pregnane glycosides whose structures were established using NMR spectroscopic analysis and chemical evidence. The aglycones of most of these compounds were identified as 8,12;8,20-diepoxy-8,14-secopregnanes, such as tuberogenin or 5,6-didehydrotuberogenin, the same aglycones as constituents of the aerial parts of this plant. Some of these compounds also caused proliferation of skin fibroblasts.
从马兜铃科植物马兜铃的根部提取的一种孕甾烷糖苷类化合物可促进正常人皮肤成纤维细胞增殖。该糖苷类化合物包含 21 种孕甾烷糖苷，其结构是通过核磁共振波谱分析和化学证据确定的。这些化合物的大多数苷元被鉴定为 8,12;8,20-环氧-8,14-孕甾烷，如马兜铃苦素或 5,6-二脱氢马兜铃苦素，这些苷元也是该植物地上部分的组成成分。其中一些化合物也能促进皮肤成纤维细胞增殖。
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