Fahy Eoin, Cotter Dawn, Sud Manish, Subramaniam Shankar
University of California, San Diego, La Jolla, CA, USA.
Biochim Biophys Acta. 2011 Nov;1811(11):637-47. doi: 10.1016/j.bbalip.2011.06.009. Epub 2011 Jun 16.
The study of lipids has developed into a research field of increasing importance as their multiple biological roles in cell biology, physiology and pathology are becoming better understood. The Lipid Metabolites and Pathways Strategy (LIPID MAPS) consortium is actively involved in an integrated approach for the detection, quantitation and pathway reconstruction of lipids and related genes and proteins at a systems-biology level. A key component of this approach is a bioinformatics infrastructure involving a clearly defined classification of lipids, a state-of-the-art database system for molecular species and experimental data and a suite of user-friendly tools to assist lipidomics researchers. Herein, we discuss a number of recent developments by the LIPID MAPS bioinformatics core in pursuit of these objectives.
随着脂质在细胞生物学、生理学和病理学中的多种生物学作用得到更深入的了解，脂质研究已发展成为一个日益重要的研究领域。脂质代谢物和途径战略（LIPID MAPS）联盟积极参与一种综合方法，用于在系统生物学水平上检测、定量脂质以及相关基因和蛋白质，并重建其途径。该方法的一个关键组成部分是一个生物信息学基础设施，包括对脂质进行明确定义的分类、用于分子种类和实验数据的先进数据库系统以及一套方便用户的工具，以协助脂质组学研究人员。在此，我们讨论了LIPID MAPS生物信息学核心为实现这些目标所取得的一些最新进展。
