Division of Human Biology, Faculty of Medicine and Health, International Medical University, 57000 Kuala Lumpur, Malaysia.
Neurosci Lett. 2011 Aug 15;500(2):139-43. doi: 10.1016/j.neulet.2011.06.021. Epub 2011 Jun 17.
An increasing large body of research on Parkinson's disease (PD) has focused on the understanding of the mechanisms behind the potential neuro protection offered by antioxidants and iron chelating agents. In this study, the protective effect of the bioflavonoid quercetin on 6-hydroxydopamine (6-OHDA)-induced model of PD was investigated. PD was induced by a single intracisternal injection of 6-hydroxydopamine (300μg) to male Sprague-Dawley rats. Quercetin treatment (30mg/kg body weight) over 14 consecutive days markedly increased the striatal dopamine and antioxidant enzyme levels compared with similar measurements in the group treated with 6-OHDA alone. There was a significant decrease in protein carbonyl content in the striatum compared with that of rats that did not receive quercetin. A significant increase in neuronal survivability was also found with quercetin treatment in rats administered 6-OHDA. In conclusion, treatment with quercetin defended against the oxidative stress in the striatum and reduced the dopaminergic neuronal loss in the rat model of PD.
越来越多的帕金森病（PD）研究集中在理解抗氧化剂和铁螯合剂提供潜在神经保护作用的机制上。在这项研究中，研究了生物类黄酮槲皮素对 6-羟多巴胺（6-OHDA）诱导的 PD 模型的保护作用。通过向雄性 Sprague-Dawley 大鼠脑室内单次注射 6-羟多巴胺（300μg）诱导 PD。与单独用 6-OHDA 处理的组相比，连续 14 天用 30mg/kg 体重的槲皮素处理显著增加纹状体中的多巴胺和抗氧化酶水平。与未接受槲皮素治疗的大鼠相比，纹状体中的蛋白质羰基含量显著降低。用 6-OHDA 处理的大鼠用槲皮素处理也发现神经元存活率显著增加。总之，槲皮素治疗可抵抗纹状体中的氧化应激并减少 PD 大鼠模型中多巴胺能神经元的丢失。
