Zbarsky Virginia, Datla Krishna P, Parkar Shabnam, Rai Deepal K, Aruoma Okezie I, Dexter David T
Imperial College London, Charing Cross Hospital, Faculty of Medicine, Department of Cellular and Molecular Neuroscience, Fulham Palace Road, London, W6 8RF, UK.
Free Radic Res. 2005 Oct;39(10):1119-25. doi: 10.1080/10715760500233113.
Although the cause of dopaminergic cell death in Parkinson's disease (PD) remains unknown, oxidative stress has been strongly implicated. Because of their ability to combat oxidative stress, diet derived phenolic compounds continue to be considered as potential agents for long-term use in PD. This study was aimed at investigating whether the natural phenolic compounds curcumin, naringenin, quercetin, fisetin can be neuroprotective in the 6-OHDA model of PD. Unilateral infusion of 6-OHDA into the medial forebrain bundle produced a significant loss of tyrosine hydroxylase (TH)-positive cells in the substantia nigra (SN) as well as a decreased of dopamine (DA) content in the striata in the vehicle-treated animals. Rats pretreated with curcumin or naringenin showed a clear protection of the number of TH-positive cells in the SN and DA levels in the striata. However, neither pretreatment with quercetin nor fisetin had any effects on TH-positive cells or DA levels. The ability of curcumin and naringenin to exhibit neuroprotection in the 6-OHDA model of PD may be related to their antioxidant capabilities and their capability to penetrate into the brain.
尽管帕金森病（PD）中多巴胺能细胞死亡的原因尚不清楚，但氧化应激已被强烈认为与之相关。由于具有对抗氧化应激的能力，饮食中含有的酚类化合物一直被视为可长期用于PD的潜在药物。本研究旨在调查天然酚类化合物姜黄素、柚皮素、槲皮素、非瑟酮在6-羟基多巴胺（6-OHDA）诱导的PD模型中是否具有神经保护作用。向内侧前脑束单侧注射6-OHDA会导致溶剂处理组动物黑质（SN）中酪氨酸羟化酶（TH）阳性细胞显著减少，以及纹状体中多巴胺（DA）含量降低。用姜黄素或柚皮素预处理的大鼠，其SN中TH阳性细胞数量和纹状体中DA水平均得到明显保护。然而，用槲皮素或非瑟酮预处理对TH阳性细胞或DA水平均无任何影响。姜黄素和柚皮素在6-OHDA诱导的PD模型中表现出神经保护作用的能力，可能与其抗氧化能力以及穿透血脑屏障的能力有关。
