Klinik-Apotheke, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Fetscherstrasse 74, Dresden, Germany.
Eur J Pharm Sci. 2011 Sep 18;44(1-2):49-56. doi: 10.1016/j.ejps.2011.06.004. Epub 2011 Jun 17.
The use of infusion filters in pediatrics is controversially discussed. Their application is an excellent opportunity to prevent complications, but there are researchers, who do not see any advantage in using inline filters. This paper describes the interaction of five different drugs with a positively charged as opposed to an uncharged polyethersulfone (PES(+) versus PES(0)) membrane.
To measure the extent and the mechanism of interaction, PES(+) versus PES(0) membranes and furosemide sodium, potassium canrenoate, digitoxin, digoxin and adenosine, each 30μmol/l, were investigated. Salt ions with different hydrodynamic radii and different concentrations have been used in the eluents.
During furosemide sodium and potassium canrenoate filtration with PES(+), the onset of UV absorption depends on the electrolyte concentration in the eluent: the lower the electrolyte concentration the later the onset of UV absorption. A correlation between the hydrodynamic volume of the different salt ions used and the onset of UV absorption could be proven for both substances: The larger the hydrodynamic volume of the extrinsic ion, the later the onset of the UV absorption if the same electrolyte concentration was used. Due to a higher structural density of PES(+) than PES(0) a delayed onset of UV absorption during filtration of digitoxin and digoxin with the PES(+) membrane could be observed. No correlation between the hydrodynamic volume of the different salt ions used and the onset of UV absorption could be seen. With adenosine neither the filter type nor the electrolyte concentration or the hydrodynamic volume of the salt ions had an influence on the onset time of absorption.
The results obtained with the anionic drugs investigated are particularly relevant if low drug concentrations in a saltless infusion solution are applied in combination with a charged filter membrane. Therefore, for each infusion formulation, a careful selection of the filter material is essential.
儿科中输注过滤器的使用存在争议。它们的应用是预防并发症的绝佳机会，但也有研究人员认为使用在线过滤器没有任何优势。本文描述了五种不同药物与带正电荷的聚醚砜（PES（+）与 PES（0））膜与不带电荷的聚醚砜（PES（+）与 PES（0））膜相互作用。
为了测量相互作用的程度和机制，研究了 PES（+）与 PES（0）膜和呋塞米钠、钾可尼酸、地高辛、毛地黄毒苷和腺苷，每种药物浓度为 30μmol/L。在洗脱液中使用了具有不同流体力学半径和不同浓度的盐离子。
在 PES（+）过滤呋塞米钠和钾可尼酸时，紫外吸收的开始取决于洗脱液中的电解质浓度：电解质浓度越低，紫外吸收开始得越晚。可以证明对于这两种物质，使用的不同盐离子的流体力学体积与紫外吸收的开始之间存在相关性：如果使用相同的电解质浓度，则外源性离子的流体力学体积越大，紫外吸收开始得越晚。由于 PES（+）的结构密度高于 PES（0），因此在用 PES（+）膜过滤地高辛和毛地黄毒苷时，可以观察到紫外吸收开始得较晚。未观察到使用的不同盐离子的流体力学体积与紫外吸收开始之间的相关性。对于腺苷，无论是过滤器类型、电解质浓度还是盐离子的流体力学体积都不会影响吸收开始时间。
如果在无盐输注溶液中应用低药物浓度并结合带电荷的过滤器膜，则研究中获得的阴离子药物的结果特别重要。因此，对于每种输注制剂，都需要仔细选择过滤器材料。
