Butler D L, Munson J M, DeLuca P P
Am J Hosp Pharm. 1980 Jul;37(7):935-41.
Simulating actual conditions of intravenous infusion, a number of routinely used additive drugs were tested for potential binding to an inline i.v. filter containing a cellulose ester membrane. Two infusion solutions, 5% dextrose and 0.9% sodium chloride, were used to deliver the drugs. Drug samples were assayed before and after passage through the filter by the following methods: bleomycin sulfate, cyanocobalamin, ergonovine maleate, mithramycin, vinblastine sulfate, and vincristine sulfate by direct spectrophotometry; oxytocin by biological assay; levarterenol by fluorescence; and folic acid, heparin, insulin, and digitoxin by radiotracer methods. Measurable reduction in potency occurred in both infusion solutions with digitoxin, insulin, mithramycin, and vincristine sulfate. No reduction in potency was observed in either infusion solution with bleomycin sulfate, cyanocobalamin, ergonovine maleate, folic acid, heparin, leverterenol bitartrate, oxytocin, and vinblastine sulfate. The study results indicate that the potency of drugs administered intravenously in small doses could be significantly reduced during inline filtration through a filter containing a cellulose ester membrane.
模拟静脉输注的实际情况，对一些常用的添加药物进行了测试，以检测其与含有纤维素酯膜的在线静脉过滤器的潜在结合情况。使用两种输注溶液，即5%葡萄糖和0.9%氯化钠来输送药物。通过以下方法对药物样品通过过滤器前后进行分析：硫酸博来霉素、氰钴胺、马来酸麦角新碱、光辉霉素、硫酸长春碱和硫酸长春新碱采用直接分光光度法；催产素采用生物测定法；去甲肾上腺素采用荧光法；叶酸、肝素、胰岛素和地高辛采用放射性示踪法。在两种输注溶液中，地高辛、胰岛素、光辉霉素和硫酸长春新碱的效价均出现了可测量的降低。在两种输注溶液中，硫酸博来霉素、氰钴胺、马来酸麦角新碱、叶酸、肝素、重酒石酸去甲肾上腺素、催产素和硫酸长春碱均未观察到效价降低。研究结果表明，小剂量静脉给药的药物在通过含有纤维素酯膜的过滤器进行在线过滤时，其效价可能会显著降低。
