Department of Pediatrics, Hanyang University School of Medicine, 17 Haengdang-Dong, Seoul, Korea.
Ann Allergy Asthma Immunol. 2011 Jul;107(1):14-21. doi: 10.1016/j.anai.2011.03.013. Epub 2011 Apr 22.
Exercise-induced bronchoconstriction (EIB), a form of bronchial hyperresponsiveness (BHR), is common in children with asthma or obesity. Epidemiological studies have shown that asthma and obesity are increasing in parallel, but obesity- and adipokine-related effects on inflammation and BHR have not yet been demonstrated in the human airway.
To address the relationship between leptin and adiponectin and EIB in children with asthma.
Eighty-five prepubertal children between the ages of 6 and 10 years were included in our study. They comprised obese with asthma (n = 19), normal weight with asthma (n = 23), obese without asthma (n = 23), and healthy (n = 20). We measured serum leptin and adiponectin levels. We also performed pulmonary function tests: baseline, postbronchodilator inhalation, methacholine inhalation, and exercise. The area under the forced expiratory volume in 1 second (FEV(1))-time curve quantified the severity of EIB over a 20-minute period after exercise (AUC(20)).
The obese children had significantly elevated levels of leptin and reduced levels of adiponectin. The maximum decreases in %FEV(1) and AUC(20) after exercise were positively correlated with leptin levels and negatively with serum adiponectin levels in children with asthma. The odds for having EIB were incrementally and significantly higher for children with higher levels of serum leptin.
Levels of the adipocyte-derived hormones leptin and adiponectin are significantly correlated with BHR induced by exercise challenge in children with asthma. Further studies are needed to elucidate whether the changes in leptin and adiponectin levels bear a causal relationship to the EIB/BHR.
运动诱发性支气管收缩（EIB）是一种支气管高反应性（BHR），在哮喘或肥胖儿童中很常见。流行病学研究表明，哮喘和肥胖呈平行增长，但肥胖和脂肪因子对炎症和 BHR 的影响尚未在人类气道中得到证实。
探讨瘦素和脂联素与哮喘儿童 EIB 的关系。
我们的研究纳入了 85 名 6 至 10 岁的青春期前儿童，包括肥胖合并哮喘组（n = 19）、正常体重合并哮喘组（n = 23）、肥胖不合并哮喘组（n = 23）和健康对照组（n = 20）。我们测量了血清瘦素和脂联素水平。还进行了肺功能测试：基础值、支气管扩张剂吸入后、乙酰甲胆碱吸入后和运动后。用力呼气 1 秒量（FEV1）时间曲线下面积定量了运动后 20 分钟内 EIB 的严重程度（AUC20）。
肥胖儿童的瘦素水平显著升高，脂联素水平降低。哮喘儿童运动后 %FEV1 和 AUC20 的最大下降与瘦素水平呈正相关，与血清脂联素水平呈负相关。血清瘦素水平较高的儿童发生 EIB 的可能性逐渐显著增加。
脂肪细胞衍生激素瘦素和脂联素的水平与哮喘儿童运动激发的 BHR 显著相关。需要进一步研究来阐明瘦素和脂联素水平的变化是否与 EIB/BHR 有因果关系。
