Webb T A, Dick T T, Blick K E, Sinn C M
Department of Pathology, Methodist Hospital, Peoria, Ill.
Indiana Med. 1990 Aug;83(8):564-7.
Recent reports have suggested that serum creatine kinase isoenzyme BB (CK-BB) may be used as a tumor marker for a variety of malignancies, particularly prostatic carcinoma. Two cases of small cell anaplastic carcinoma of the lung (SCAC) had markedly contrasting levels of CK-BB by serum electrophoresis. Retrospective analysis of the index cases, and four additional autopsy cases of SCAC, included: 1) quantitation of CK-B in postmortem tumor and adjacent non-tumor lung tissue; 2) enzymatic and radioimmunoassay serum levels of CK-B; and 3) CK-B immunoperoxidase staining of tumor and non-tumor tissues for CK-B. Serum CK-BB is a non-specific tumor marker, but its presence, in whatever amount, should alert the clinician to the possibility of an associated malignancy, particularly SCAC or metastatic carcinoma.
最近的报告表明，血清肌酸激酶同工酶BB（CK-BB）可能用作多种恶性肿瘤的肿瘤标志物，尤其是前列腺癌。两例肺小细胞间变性癌（SCAC）患者经血清电泳显示CK-BB水平形成显著对比。对索引病例以及另外4例SCAC尸检病例进行回顾性分析，包括：1）对尸检肿瘤及相邻非肿瘤肺组织中的CK-B进行定量分析；2）对血清中CK-B进行酶法和放射免疫分析；3）对肿瘤和非肿瘤组织进行CK-B免疫过氧化物酶染色。血清CK-BB是一种非特异性肿瘤标志物，但其无论含量多少，都应提醒临床医生存在相关恶性肿瘤的可能性，尤其是SCAC或转移性癌。
