Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China.
Acta Histochem. 2013 Jan;115(1):3-7. doi: 10.1016/j.acthis.2011.05.002. Epub 2011 Jun 25.
Previous investigations on galectin-3 (gal-3) have focused mainly on its role in some malignant tumors. It was believed that gal-3 plays important roles in cell proliferation, apoptosis and adhesion in many cell types. Recently, gal-3 has been recognized as a factor related to endometrial receptivity in the human endometrium and trophoblast during embryo implantation. Human chorionic gonadotropin (hCG) is a specific embryonic hormone providing a signal from the embryo involved in preparing the receptive endometrium for embryo implantation. The current study aimed to determine whether hCG regulates gal-3 expression in endometrial cells. Our results showed that expression of gal-3 in both endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) could be regulated by hCG in an intricate manner. These results indicate that gal-3 might be regulated by hCG in preparing the endometrium for embryonic implantation.
先前关于半乳糖凝集素-3（galectin-3，gal-3）的研究主要集中在其在某些恶性肿瘤中的作用。人们认为 gal-3 在许多细胞类型的细胞增殖、凋亡和黏附中发挥重要作用。最近，gal-3 已被认为是人类子宫内膜和胚胎植入过程中滋养层中与子宫内膜容受性相关的因素。人绒毛膜促性腺激素（human chorionic gonadotropin，hCG）是一种特定的胚胎激素，为胚胎提供参与准备接受胚胎植入的子宫内膜的信号。本研究旨在确定 hCG 是否调节子宫内膜细胞中 gal-3 的表达。我们的结果表明，hCG 可以以复杂的方式调节子宫内膜上皮细胞（endometrial epithelial cells，EECs）和子宫内膜基质细胞（endometrial stromal cells，ESCs）中 gal-3 的表达。这些结果表明，gal-3 可能受 hCG 调节，以准备胚胎植入的子宫内膜。
