Vascular Disease Research Center, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA.
J Vasc Interv Radiol. 2011 Aug;22(8):1077-82. doi: 10.1016/j.jvir.2011.04.008. Epub 2011 Jun 25.
To determine the prevalence of an abnormal ankle-brachial index (ABI) among subjects not considered to be at high risk for cardiovascular disease (CVD) based on the Framingham Risk Score (FRS).
Data from the Population-Based Examinations to Determine Ankle-brachiaL index (PEDAL) Study (2007-2009), a cross-sectional study at 23 U.S. sites, in conjunction with Legs for Life, a national ABI screening program, were analyzed. This study includes data from 822 participants (average age 64.3 years ± 11.6, 69.7% women, 89.7% non-Hispanic white) without known CVD or diabetes, who were screened for peripheral artery disease (PAD) with an ABI and for whom all FRS variables were available. Participants' 10-year coronary heart disease (CHD) risk was estimated from the FRS, and three risk categories were defined: low (< 10%), intermediate (10%-19%), and high (≥ 20%). ABI < 0.90 or > 1.4 in either leg was considered abnormal.
The prevalence of abnormal ABI was 14.2% (95%confidence interval [CI] 11.9%-16.8%). According to the FRS, 463 (56.3%) participants were at low risk, 212 (25.8%) were at intermediate risk, and 147 (17.9%) were at high risk. Among participants with a low FRS (n = 463; without CVD or diabetes or both) and an intermediate FRS (n = 212; without CVD or diabetes or both), 12.3% and 12.2% had an abnormal ABI.
The prevalence of abnormal ABI, a CHD equivalent, is high among individuals not identified as high risk by conventional Framingham-based risk assessment.
根据弗雷明汉风险评分（Framingham Risk Score，FRS），确定未被认为存在心血管疾病（cardiovascular disease，CVD）高风险的人群中异常踝臂指数（ankle-brachial index，ABI）的流行率。
该研究为一项横断面研究，共纳入 23 个美国地点的人群基础检查以确定踝臂指数（Population-Based Examinations to Determine Ankle-brachiaL index，PEDAL）研究的数据，同时还纳入了一个全国性的 ABI 筛查项目“Legs for Life”的数据。该研究共纳入 822 名参与者（平均年龄 64.3 岁±11.6 岁，69.7%为女性，89.7%为非西班牙裔白人），无已知 CVD 或糖尿病病史，参与者接受了 ABI 筛查以确定外周动脉疾病（peripheral artery disease，PAD），并可获得所有 FRS 变量的数据。根据 FRS 评估参与者的 10 年冠心病（coronary heart disease，CHD）风险，并将风险分为低危（< 10%）、中危（10%-19%）和高危（≥ 20%）。ABI<0.90 或>1.4 被认为是异常的。
异常 ABI 的患病率为 14.2%（95%置信区间 [confidence interval，CI] 11.9%-16.8%）。根据 FRS，463 名（56.3%）参与者为低危，212 名（25.8%）为中危，147 名（17.9%）为高危。在低 FRS（n = 463；无 CVD 或糖尿病或两者均无）和中 FRS（n = 212；无 CVD 或糖尿病或两者均无）的参与者中，分别有 12.3%和 12.2%存在异常 ABI。
在未被传统基于弗雷明汉风险评估确定为高危的个体中，异常 ABI（CHD 等效指标）的患病率较高。
