Department of Medicine, Pamela Youde Nethersole Eastern Hospital, 3rd Lok Man Road, Chai Wan, Hong Kong Special Administrative Region, China.
Parkinsonism Relat Disord. 2011 Sep;17(8):635-7. doi: 10.1016/j.parkreldis.2011.06.001. Epub 2011 Jun 25.
We studied the prevalence and related risk factors of impulse control disorders in Chinese Parkinson's disease patients.
We screened all non-demented Parkinson's disease patients attending our Parkinson's disease clinic from August 2009 to March 2010. The clinical characteristics of patients with impulse control disorders and those without were compared.
Of the 213 PD subjects screened, 15 (7.0%) with impulse control disorders were identified. Fourteen of these subjects were on both a dopamine agonist and Levodopa, and one was on Levodopa alone. Of the fourteen subjects on both a dopamine agonist and Levodopa, eleven were on bromocriptine and Levodopa; 10.5% of the subjects exposed to bromocriptine had impulse control disorder. Upon multivariate analysis, dose of dopamine agonist used, young age at onset of Parkinson's disease and a history of anxiety or depression were independent predictors for developing impulse control disorders.
7% of our Chinese PD subjects had impulse control disorders. When young Parkinson's disease patients with a history of anxiety or depression are treated with high dose of DA, they are at risk of developing impulse control disorders.
我们研究了冲动控制障碍在我国帕金森病患者中的流行情况及相关危险因素。
我们于 2009 年 8 月至 2010 年 3 月间筛选了所有在我院帕金森病门诊就诊的非痴呆帕金森病患者。比较了患有冲动控制障碍患者与未患有冲动控制障碍患者的临床特征。
在筛查的 213 例 PD 患者中，发现 15 例（7.0%）患有冲动控制障碍。其中 14 例患者同时服用多巴胺激动剂和左旋多巴，1 例患者仅服用左旋多巴。在服用多巴胺激动剂和左旋多巴的 14 例患者中，有 11 例服用溴隐亭和左旋多巴；服用溴隐亭的患者中有 10.5%患有冲动控制障碍。多变量分析显示，多巴胺激动剂的使用剂量、帕金森病发病年龄较小和焦虑或抑郁病史是发生冲动控制障碍的独立预测因素。
我们的研究中，7%的中国 PD 患者患有冲动控制障碍。当年轻的帕金森病患者有焦虑或抑郁病史，并接受高剂量 DA 治疗时，他们有发生冲动控制障碍的风险。
