School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.
Chem Commun (Camb). 2011 Aug 7;47(29):8262-4. doi: 10.1039/c1cc12922h. Epub 2011 Jun 24.
Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.
诱导形成高级 DNA 结构的小分子具有潜在的治疗和纳米技术应用。点击文库的筛选已经确定了第一种在室温下诱导形成霍利迪交叉结构的化合物，而不需要高温退火步骤。
