铜（II）阳离子诱导可逆的DNA i-基序向发夹结构转变
Reversible DNA i-motif to hairpin switching induced by copper(II) cations.
作者信息
Day Henry Albert, Wright Elisé Patricia, MacDonald Colin John, Gates Andrew James, Waller Zoë Ann Ella
机构信息
School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
出版信息
Chem Commun (Camb). 2015 Sep 25;51(74):14099-102. doi: 10.1039/c5cc05111h.
Abstract
i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.
摘要
i-基序DNA结构此前已被用于许多不同的纳米技术应用中，但所有这些应用都利用了pH值的变化来折叠DNA。在此，我们描述了铜（II）阳离子如何能将i-基序DNA的构象改变为另一种发夹结构，而通过与乙二胺四乙酸（EDTA）螯合，这种改变是可逆的。
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