Department of Anesthesiology, Singapore General Hospital, Outram Road, Block 2 Level 2, Singapore General Hospital, S169608, Singapore, Singapore.
J Anesth. 2011 Oct;25(5):756-9. doi: 10.1007/s00540-011-1189-1. Epub 2011 Jun 25.
We report on five patients who underwent MRI-guided focused ultrasound ablation of prostatic cancer under epidural anesthesia with intravenous dexmedetomidine sedation. This pioneering procedure requires an immobile therapeutic field with adequate sedation and analgesia provided to the patients. Duration of the procedure is longer compared to diagnostic MRI scans. In combination with epidural anesthesia, dexmedetomidine was used to provide moderate levels of sedation without causing respiratory depression or hemodynamic instability, and was useful in preventing shivering. The pharmacological properties of dexmedetomidine contribute to make this technique safe and effective.
我们报告了五例在硬膜外麻醉下静脉给予右美托咪定镇静下接受 MRI 引导聚焦超声治疗前列腺癌的患者。这项开创性的手术需要一个固定的治疗区域，并为患者提供足够的镇静和镇痛。与诊断性 MRI 扫描相比，该手术的持续时间更长。与硬膜外麻醉联合使用时，右美托咪定用于提供适度镇静水平，而不会引起呼吸抑制或血流动力学不稳定，并有助于预防寒战。右美托咪定的药理学特性使其成为一种安全有效的技术。
