Kimura Sho, Yoneda Chihiro, Hashimoto Naotake, Hamada Hiromichi, Terai Masaru
Department of Pediatrics, Tokyo Womens Medical University, Yachiyo Medical Center.
Kansenshogaku Zasshi. 2011 May;85(3):272-4. doi: 10.11150/kansenshogakuzasshi.85.272.
Encephalopathy with reversible lesion of the corpus callosum splenium has a favorable prognosis, but that in 2009 influenza A/H1N1 is unknown. We report a case of clinically mild encephalopathy with a reversible lesion of the corpus callosum splenium in which 2009 influenza A/H1N1 virus was confirmed by laboratory tests. A 15-year-old Japanese girl seen at the emergency unit for loss of consciousness 18 hours after fever onset had been diagnosed with influenza A, and administered zanamivir. Diffusion-weighted magnetic resonance imaging (MRI) indicated lesions of the corpus callosum splenium, and electroencephalography showed slow basic activity, suggesting influenza A related to encephalopathy. She required intensive care with ventilation for two days. Her consciousness had become normal by day 6 after onset, and MRI findings improved on day 7. She recovered without adverse sequelae.
伴有胼胝体压部可逆性病变的脑病预后良好，但2009年甲型H1N1流感所致的此类脑病预后尚不清楚。我们报告一例临床上轻度的伴有胼胝体压部可逆性病变的脑病病例，该病例经实验室检测确诊为2009年甲型H1N1流感病毒感染。一名15岁日本女孩，发热18小时后因意识丧失被送至急诊室，诊断为甲型流感，并给予扎那米韦治疗。弥散加权磁共振成像（MRI）显示胼胝体压部有病变，脑电图显示基础活动缓慢，提示甲型流感与脑病有关。她需要接受两天的重症监护及通气治疗。发病后第6天她的意识恢复正常，第7天MRI检查结果有所改善。她康复后未留下后遗症。
