Wojtecki Lars, Timmermann Lars, Groiss Stefan Jun, Elben Saskia, Reck Christiane, Südmeyer Martin, Sturm Volker, Schnitzler Alfons
Institute of Clinical Neuroscience and Medical Psychology & Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany.
Neurocase. 2011 Dec;17(6):527-32. doi: 10.1080/13554794.2010.547507. Epub 2011 Jun 27.
The mechanism and time course of emotional side effects of subthalamic deep brain stimulation in Parkinson's disease are a matter for discussion. We report a 53-month follow-up of a patient with affective lability. Postoperative lesion plus bilateral stimulation strongly influenced mood in the first week in terms of laughing behavior, while voltage changes had only minor long-term impact up to 37 months on negative emotion, possibly caused by the right electrode stimulating the subthalamic nucleus and adjacent fiber tracts involving the internal capsule. Thus we conclude that affective lability can occur with different temporal dynamics of microlesion, and early and chronic stimulation.
丘脑底核深部脑刺激治疗帕金森病时情绪副作用的机制和时间进程尚待探讨。我们报告了一例情感不稳定患者的53个月随访情况。术后损伤加双侧刺激在第一周对笑行为方面的情绪有强烈影响，而电压变化在长达37个月的时间里对负面情绪只有轻微的长期影响，这可能是由于右侧电极刺激丘脑底核及涉及内囊的相邻纤维束所致。因此我们得出结论，情感不稳定可因微损伤、早期刺激和慢性刺激的不同时间动态变化而发生。
