Wojtecki Lars, Nickel Janpeter, Timmermann Lars, Maarouf Mohammad, Südmeyer Martin, Schneider Frank, Seitz Rüdiger J, Voges Jürgen, Sturm Volker, Schnitzler Alfons
Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.
Mov Disord. 2007 Jul 15;22(9):1314-6. doi: 10.1002/mds.21266.
Pathological crying (PLC)--an affective gesture without any or an adequate emotion--occurs with various diseases. A recent theory suggests that PLC is caused by a disruption of higher order cortical association areas from the cerebellum which computes profiles of psychomotor responses. We report a patient with Parkinson's disease who developed PLC during stimulation of the subthalamic nucleus (STN) predominantly of the right hemisphere. Positron emission tomography imaging showed thalamo-ponto-cerebellar activation during such stimulation. These findings indicate that the STN and possibly also ponto-cerebellar pathways are involved in psychomotor control and in the modulation of PLC.
病理性哭泣（PLC）——一种没有任何情感或情感不恰当的情感姿态——在多种疾病中都会出现。最近的一种理论认为，PLC是由小脑对高阶皮质联合区的破坏引起的，小脑负责计算精神运动反应的特征。我们报告了一名帕金森病患者，在刺激主要位于右半球的丘脑底核（STN）时出现了PLC。正电子发射断层扫描成像显示，在这种刺激过程中丘脑-脑桥-小脑被激活。这些发现表明，STN以及可能的脑桥-小脑通路参与了精神运动控制和PLC的调节。
