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德克萨斯羽扇豆中的类黄酮及其自由基清除活性。

Flavonoids from Lupinus texensis and their free radical scavenging activity.

机构信息

National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, Texas 75962-6109, USA.

出版信息

Nat Prod Res. 2011 Oct;25(17):1641-9. doi: 10.1080/14786419.2010.523423. Epub 2011 Jun 27.

DOI:10.1080/14786419.2010.523423
PMID:21707249
Abstract

Seventeen flavonoids including one new compound were isolated from Texas bluebonnet (Lupinus texensis), the state flower of Texas. Their structures were determined by extensive nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry analyses. High-performance liquid chromatography analytic method for simultaneous determination of the 17 compounds was established and validated. Eleven isolated flavonoids were first evaluated for their free radical scavenging activity using α,α-diphenyl-β-picrylhydrazyl scavenging assay and they showed activity with EC(50) 48.6-172.5 µg mL(-1).

摘要

从德克萨斯州的州花得克萨斯蓝铃花(Lupinus texensis)中分离出 17 种类黄酮,其中包括一种新化合物。通过广泛的核磁共振和高分辨率电喷雾电离质谱分析确定了它们的结构。建立并验证了同时测定 17 种化合物的高效液相色谱分析方法。首次使用α,α-二苯基-β-苦基肼自由基清除测定法对 11 种分离出的类黄酮的自由基清除活性进行了评估,其 EC(50)为 48.6-172.5 µg mL(-1)。

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