Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Parasite Immunol. 2012 Feb-Mar;34(2-3):100-7. doi: 10.1111/j.1365-3024.2011.01311.x.
The Wellcome Trust Sanger Institute (WTSI) is producing de novo reference quality genomes for parasitic helminth species from platyhelminth tapeworms (cestodes), flukes (trematodes) and roundworms (nematodes) primarily using second-generation (Illumina and 454) sequencing technologies. The reference genomes will be followed with draft coverage from a number of related strains or species. Comparing species- or strain-specific differences will help to unravel the genomic basis for differences in the organism's biology and ultimately contribute towards identifying potential novel targets for vaccine therapies. Second-generation sequencing technologies are revolutionizing parasite genomics. This article reviews the impact that sequencing technologies has had on genomics and how it has shaped the parasitic helminth genome sequencing initiative at WTSI.
威康信托桑格研究所（WTSI）正在使用第二代（Illumina 和 454）测序技术，为扁形动物门的寄生扁形动物（绦虫）、吸虫（吸虫）和线虫（线虫）的物种从头生成参考质量的基因组。参考基因组之后将来自许多相关菌株或物种的草图覆盖率。比较物种或菌株特异性差异将有助于揭示生物体生物学差异的基因组基础，并最终有助于确定疫苗治疗的潜在新靶标。第二代测序技术正在彻底改变寄生虫基因组学。本文综述了测序技术对寄生虫基因组学的影响，以及它如何塑造 WTSI 的寄生扁形动物基因组测序计划。
