Barcelona Centre for International Health Research, Hospital Clínic/Institut d'Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.
Trop Med Int Health. 2011 Sep;16(9):1054-60. doi: 10.1111/j.1365-3156.2011.02811.x. Epub 2011 Jun 28.
To determine the epidemiology and clinical presentation of virus-associated acute respiratory infections (ARI) in Mozambican infants.
A systematic selection of nasopharyngeal aspirates (n = 333), collected from infants younger than 12 months who visited Manhiça District Hospital (southern Mozambique) with ARI during a 12 months respiratory syncitial virus surveillance, were tested for other common respiratory viruses. Four different polymerase chain reactions were used to diagnose rhinovirus (RV), influenza (Flu; A and B), adenovirus (ADV), human metapneumovirus (hMPV), parainfluenza (PIV; 1, 2, 3 and 4AB) and enterovirus (EV).
At least one study virus was identified in more than half of the samples tested (185/333). Overall, 231 viruses were detected among 185 infants, listed in the order of prevalence: RV (26%), Flu (15%), ADV (14%), hMPV (7%), PIV (5%) and EV (3%). Acute respiratory infections (ARI) cases and viral episodes were seasonal and concentrate during the warm and the rainy season. Clinical features were similar among all study children regardless of the detection of virus, with the exception of ear discharge, which was more frequent among viral cases [6% (11/183) vs. 1% (2/144); P = 0.034]. Children with multiple viral infections had higher odds of severity such as nasal flaring and indrawing (OR = 2.7, P = 0.028 and OR = 3.8, P = 0.007, respectively) and higher odds of hospitalisation (OR = 4.42, P = 0.001, adjusted by age and sex).
Viral ARI are frequent among infants visited in MHD. Strategies to prevent mild respiratory infections, and specially their complications, might alleviate health systems of source-limited settings.
确定莫桑比克婴儿与病毒相关的急性呼吸道感染（ARI）的流行病学和临床特征。
在一项为期 12 个月的呼吸道合胞病毒监测中，系统地选择了 333 名年龄在 12 个月以下、因 ARI 就诊于马希奇区医院（莫桑比克南部）的婴儿的鼻咽抽吸物（nasopharyngeal aspirates）进行检测，以检测其他常见呼吸道病毒。使用四种不同的聚合酶链反应来诊断鼻病毒（RV）、流感（Flu；A 和 B）、腺病毒（ADV）、人偏肺病毒（hMPV）、副流感（PIV；1、2、3 和 4AB）和肠病毒（EV）。
在所检测的样本中，超过一半（185/333）至少检测到一种研究病毒。总体而言，在 185 名婴儿中检测到 231 种病毒，按流行率顺序列出：RV（26%）、Flu（15%）、ADV（14%）、hMPV（7%）、PIV（5%）和 EV（3%）。ARI 病例和病毒发作呈季节性，集中在温暖和雨季。所有研究儿童的临床特征相似，无论是否检测到病毒，除了耳漏，病毒病例更为常见[6%（11/183）比 1%（2/144）；P=0.034]。患有多种病毒感染的儿童更有可能出现严重程度，如鼻翼煽动和吸气性凹陷（OR=2.7，P=0.028 和 OR=3.8，P=0.007），以及更高的住院几率（OR=4.42，P=0.001，按年龄和性别调整）。
在 MHD 就诊的婴儿中，病毒引起的 ARI 很常见。预防轻度呼吸道感染，特别是其并发症的策略，可能会减轻资源有限地区卫生系统的负担。
