Naghipour Mohammadreza, Cuevas Luis E, Bakhshinejad Tahereh, Mansour-Ghanaei Fariborz, Noursalehi Smaeil, Alavy Ali, Dove Winifred, Hart Charles Anthony
Guilan University of Medical Sciences, Namdjoo Avenue, Rasht, Iran.
J Trop Pediatr. 2007 Jun;53(3):179-84. doi: 10.1093/tropej/fml089. Epub 2007 Feb 7.
The study reports the frequency and clinical presentation of respiratory syncytial virus (RSV), human metapneumovirus, influenza (Inf V), parainfluenza, adenovirus (Adv), Chlamydia spp. and Mycoplasma pneumoniae in children with acute respiratory infections (ARI) in Rasht, Iran. Nasopharyngeal aspirates and swabs were collected from 261 children in 2003 and 2004. Pathogens were detected using polymerase chain reaction (PCR) and reverse transcription-PCR (RT-PCR), confirmed with sequence analysis. Ninety-three pathogens were detected in 83 children. RSV was present in 39 (15%), Adv in 37 (14%), Inf A in 11 (4%), C. trachomatis in 4 (2%) and M. pneumoniae, in 2 (1%) children. Neither parainfluenza nor metapneumovirus were detected. RSV, Inf A and C. trachomatis were more frequent in children with lower respiratory infections. Adv presented more frequently as upper respiratory infection. All pathogens, except M. pneumoniae, were detected in children with severe pneumonia. Viruses play a significant role in Iranian children with community-acquired ARI.
该研究报告了伊朗拉什特急性呼吸道感染（ARI）儿童中呼吸道合胞病毒（RSV）、人偏肺病毒、流感病毒（Inf V）、副流感病毒、腺病毒（Adv）、衣原体属和肺炎支原体的感染频率及临床表现。2003年和2004年从261名儿童中采集了鼻咽抽吸物和拭子。使用聚合酶链反应（PCR）和逆转录PCR（RT-PCR）检测病原体，并通过序列分析进行确认。在83名儿童中检测到93种病原体。39名（15%）儿童感染RSV，37名（14%）感染Adv，11名（4%）感染甲型流感病毒，4名（2%）感染沙眼衣原体，2名（1%）感染肺炎支原体。未检测到副流感病毒和人偏肺病毒。RSV、甲型流感病毒和沙眼衣原体在患有下呼吸道感染的儿童中更为常见。Adv更多表现为上呼吸道感染。除肺炎支原体外，所有病原体均在重症肺炎儿童中检测到。病毒在伊朗社区获得性ARI儿童中起重要作用。
