Department of Modeling of Biological Processes, COS Heidelberg/BioQuant, University of Heidelberg, Germany.
FEBS J. 2011 Aug;278(16):2767-857. doi: 10.1111/j.1742-4658.2011.08217.x. Epub 2011 Jul 26.
Systems biology has received an ever increasing interest during the last decade. A large amount of third-party funding is spent on this topic, which involves quantitative experimentation integrated with computational modeling. Industrial companies are also starting to use this approach more and more often, especially in pharmaceutical research and biotechnology. This leads to the question of whether such interest is wisely invested and whether there are success stories to be told for basic science and/or technology/biomedicine. In this review, we focus on the application of systems biology approaches that have been employed to shed light on both biochemical functions and previously unknown mechanisms. We point out which computational and experimental methods are employed most frequently and which trends in systems biology research can be observed. Finally, we discuss some problems that we have encountered in publications in the field.
系统生物学在过去十年中受到了越来越多的关注。大量的第三方资金用于这个涉及定量实验与计算建模相结合的课题。工业公司也开始越来越多地采用这种方法，尤其是在制药研究和生物技术领域。这就引出了一个问题，即这种关注是否明智地投资，以及是否有基础科学和/或技术/生物医学方面的成功故事可以讲述。在这篇综述中，我们专注于系统生物学方法的应用，这些方法被用来阐明生化功能和以前未知的机制。我们指出了最常使用的计算和实验方法，以及可以观察到的系统生物学研究趋势。最后，我们讨论了我们在该领域的出版物中遇到的一些问题。
