Fa Zhiqiang, Zhang Peng, Wu Weiwei, Wang Zhijuan, Huang Fanheng, Yang Lujun, Chang Haigang, Xu Ruxiang, Wen Zhibo, Zhang Jing, Zeng Yanjun, Jiang Xiaodan
Department of Neurosurgery, Zhujiang Hospital, Guangzhou, China.
Neurol Res. 2011 Jul;33(6):563-71. doi: 10.1179/1743132810Y.0000000009.
Functional neuroimaging techniques act as the navigator to assess changes in brain activity induced by repetitive transcranial magnetic stimulation (rTMS) in rTMS studies. The aim of this study was to investigate the feasibility of using manganese-enhanced magnetic resonance imaging (MEMRI) to measure the brain activity in rTMS studies.
Eighteen Wistar rats were randomized into three groups (n = 6) including a high rTMS group, a low rTMS group and a sham stimulation group (controls). They were given rTMS of 10 Hz, 1 Hz or sham stimulation for 5 hours separately. MEMRI was used to assess the changes of brain activity.
Compared with the controls, image intensity was enhanced differently in various brain regions on T1-weighted images after rTMS with different frequencies, higher intensity and wider enhancement occurred in the high frequency rTMS group as compared with that in the low frequency rTMS group.
MEMRI can be used to reveal the changes of brain activity in live rats following rTMS.
The current experiment might provide a new functional neuroimaging technique for the study of rTMS.
在重复经颅磁刺激（rTMS）研究中，功能神经成像技术充当评估rTMS诱导的脑活动变化的导航工具。本研究的目的是探讨使用锰增强磁共振成像（MEMRI）测量rTMS研究中脑活动的可行性。
将18只Wistar大鼠随机分为三组（n = 6），包括高频rTMS组、低频rTMS组和假刺激组（对照组）。分别给予它们10Hz、1Hz的rTMS或假刺激，持续5小时。使用MEMRI评估脑活动的变化。
与对照组相比，不同频率的rTMS后，T1加权图像上各脑区的图像强度增强情况不同，高频rTMS组的强度更高且增强范围更广，与低频rTMS组相比差异明显。
MEMRI可用于揭示rTMS后活鼠脑活动的变化。
本实验可能为rTMS研究提供一种新的功能神经成像技术。
