Department of Oral Anatomy, Neurobiology, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea.
Int Rev Neurobiol. 2011;97:99-141. doi: 10.1016/B978-0-12-385198-7.00005-9.
The study of projections and synaptic connectivity of trigeminal sensory and proprioceptive afferents in the 1(st) relay nucleus of the brainstem, helps us to understand where and how the specific craniofacial neural information is transmitted and processed in the CNS. This paper reviews recent findings on the synaptic connectivity of specific craniofacial sensory and proprioceptive afferents in the brainstem. It also deals with neurotransmitters and receptors involved in the presynaptic modulation of the trigeminal primary afferents. Here, we will also review recent findings on the projection and synaptic connectivity of the axons, and terminals in the trigeminal sensory nuclei that express nociceptive markers such as theromosensitive TRP channels TRPV1 and TRPA1, and the purinergic receptor P2X3. The dental pulp is a good model for the study of peripheral pain because it is densely innervated by nociceptive afferents. Finally, we describe the axons innervating the dental pulp and the morphological changes that the myelinated axons undergo during their intradental course.
研究三叉神经感觉和本体传入纤维在脑干第一中继核中的投射和突触连接，有助于我们了解特定的颅面神经信息在中枢神经系统中是如何以及在何处进行传递和处理的。本文综述了近年来关于脑干中特定颅面感觉和本体传入纤维的突触连接的研究发现。它还涉及到参与三叉神经初级传入纤维突触前调制的神经递质和受体。在这里，我们还将回顾近年来关于表达伤害性标记物（如热敏 TRPV1 和 TRPA1 通道和嘌呤能受体 P2X3）的三叉神经感觉核中轴突和末梢的投射和突触连接的发现。牙髓是研究外周疼痛的良好模型，因为它被伤害性传入纤维密集地支配。最后，我们描述了支配牙髓的轴突以及在牙髓内过程中有髓轴突经历的形态变化。
