Metzger Roman, Metzger Ulrike, Fiegel Henning C, Kluth Dietrich
Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany.
Semin Pediatr Surg. 2011 Aug;20(3):145-51. doi: 10.1053/j.sempedsurg.2011.03.005.
In most textbooks of embryology and pediatric surgery, the puzzling spectrum of midgut "malrotations" is explained by an "impaired" process of rotation of the midgut. However, this "process of rotation" is explained in a rather schematic way and aims more to explain pathologic findings whereas detailed embryologic investigations are still rare in this field. Good animal models which would allow the comparison of normal and abnormal midgut development are missing. In this paper we describe the development of the midgut in form of an atlas. Scanning electron microscopy is used in rat embryos to illustrate the crucial embryologic processes of midgut development. The main result shown in these illustrations is that clear signs of a process of rotation are missing.
在大多数胚胎学和小儿外科学教科书中,中肠“旋转不良”这一令人困惑的情况是通过中肠旋转“受损”过程来解释的。然而,这种“旋转过程”的解释相当简略,更多是为了解释病理结果,而该领域详细的胚胎学研究仍然很少。目前缺乏能够用于比较正常和异常中肠发育的良好动物模型。在本文中,我们以图谱的形式描述中肠的发育过程。利用扫描电子显微镜对大鼠胚胎进行观察,以阐明中肠发育的关键胚胎学过程。这些图示显示的主要结果是,未发现明显的旋转过程迹象。