Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
Development. 2020 Oct 12;147(19):dev187583. doi: 10.1242/dev.187583.
Many organs develop left-right asymmetric shapes and positions that are crucial for normal function. Indeed, anomalous laterality is associated with multiple severe birth defects. Although the events that initially orient the left-right body axis are beginning to be understood, the mechanisms that shape the asymmetries of individual organs remain less clear. Here, we summarize new evidence challenging century-old ideas about the development of stomach and intestine laterality. We compare classical and contemporary models of asymmetric gut morphogenesis and highlight key unanswered questions for future investigation.
许多器官会发育出左右不对称的形状和位置，这对于正常功能至关重要。事实上，异常的左右不对称性与多种严重的出生缺陷有关。尽管最初确定左右身体轴的事件开始被理解，但塑造单个器官不对称性的机制仍然不太清楚。在这里，我们总结了一些新的证据，这些证据对胃和肠左右不对称发育的百年观念提出了挑战。我们比较了经典和当代的不对称肠道形态发生模型，并强调了未来研究中需要回答的关键问题。
