Kluth Dietrich, Fiegel Henning C, Metzger Roman
Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany.
Semin Pediatr Surg. 2011 Aug;20(3):152-60. doi: 10.1053/j.sempedsurg.2011.03.002.
Normal and abnormal development of the hindgut is still in debate. Normal development of the hindgut critically depends on the cloacal membrane. In this study, scanning electron microscopy of staged rat embryos between the gestational days 10-15 was performed to show the normal development of the hindgut and the abnormal development in Danforth's short tail (SD) mice. Our studies in normal and abnormal development indicate that the embryonic cloaca never passes through a stage that is similar to any form of anorectal malformation in neonates, including the so-called "cloacas" in females. To explain the abnormal development in anorectal malformations, further studies are mandatory.
后肠的正常和异常发育仍存在争议。后肠的正常发育严重依赖泄殖腔膜。在本研究中，对妊娠第10 - 15天的分期大鼠胚胎进行扫描电子显微镜检查，以显示后肠的正常发育以及丹佛短尾（SD）小鼠的异常发育。我们对正常和异常发育的研究表明，胚胎泄殖腔从未经历过与新生儿任何形式的肛门直肠畸形相似的阶段，包括女性所谓的“泄殖腔”。为了解释肛门直肠畸形的异常发育，必须进行进一步研究。
