Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.
Oral Oncol. 2011 Aug;47(8):688-92. doi: 10.1016/j.oraloncology.2011.05.016. Epub 2011 Jun 25.
The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper is to describe the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies, and studying its relationship with tumoral clinical and pathological variables, and describing genetic and molecular interactions in OSCC.
c-myc 在致癌过程中的影响此前已有描述，尽管在口腔肿瘤的具体情况下，其影响尚未得到充分验证。Myc 蛋白是一组原癌基因，参与细胞增殖调控、分化和凋亡。本文的目的是描述 c-myc 的功能及其作为癌基因的作用，通过免疫组织化学和遗传扩增研究评估其表达，并研究其与肿瘤临床和病理变量的关系，并描述 OSCC 中的遗传和分子相互作用。
