人类乳头瘤病毒、疣和癌症的历史：我们今天了解多少？

History of human papillomavirus, warts and cancer: what do we know today?

机构信息

Department of Obstetrics and Gynaecology, University Hospital of South Manchester NHS Foundation Trust, UK.

出版信息

Best Pract Res Clin Obstet Gynaecol. 2011 Oct;25(5):565-74. doi: 10.1016/j.bpobgyn.2011.05.001. Epub 2011 Jun 25.

DOI:10.1016/j.bpobgyn.2011.05.001

Abstract

Human papillomavirus has been a cause of infection in humans for thousands of years. The history of papillomaviruses, knowledge of their causative role in benign and malignant disease, and their structural characteristics have led to the development of vaccines to prevent cervical and anogenital cancers. Many questions remain unanswered before HPV vaccines can be optimised; however, the concept of virtual eradication of cervical cancer is not impossible, and remains a realistic aspiration.

摘要

人乳头瘤病毒（HPV）在人类中引发感染已有数千年的历史。对 HPV 的历史、其在良性和恶性疾病中的致病作用的认识，以及它们的结构特征，促使人们开发出预防宫颈癌和肛门生殖器癌的疫苗。在 HPV 疫苗能够得到优化之前，仍有许多问题尚未得到解答；然而，彻底消除宫颈癌的概念并非不可能，仍然是一个切实的愿望。