Cecchini S, Iossa A, Ciatto S, Bonardi L, Confortini M, Cipparrone G
Center for Cancer Study and Prevention, Florence, Italy.
Obstet Gynecol. 1990 Nov;76(5 Pt 1):857-9. doi: 10.1097/00006250-199011000-00027.
A colposcopic survey was performed in 269 consecutive women with negative cytology showing hyperkeratosis or parakeratosis. A colposcopy-guided biopsy specimen of cervical abnormalities was taken in 88 cases, and human papillomavirus infection (HPV) was detected histologically in 25 cases. No cervical intraepithelial neoplasia (CIN) was detected. The detection rate of HPV was not significantly different from that observed in a consecutive series of 1073 Papanicolaou test-negative subjects self-referred for colposcopy. Colposcopic screening of subjects showing hyperkeratosis or parakeratosis with otherwise negative smears is not recommended because it does not allow detection of cytologically false-negative CIN.
对269例连续的细胞学检查阴性但显示角化过度或不全角化的女性进行了阴道镜检查。对88例宫颈异常情况进行了阴道镜引导下活检，其中25例经组织学检测发现人乳头瘤病毒（HPV）感染。未检测到宫颈上皮内瘤变（CIN）。HPV的检出率与1073例自行前来进行阴道镜检查的巴氏试验阴性的连续病例系列中观察到的检出率无显著差异。不建议对涂片其他结果为阴性但显示角化过度或不全角化的受试者进行阴道镜筛查，因为这无法检测出细胞学假阴性的CIN。
