Sorosky J I, Kaminski P F, Wheelock J B, Podczaski E S
Department of Obstetrics and Gynecology, Milton S. Hershey Medical Center of Pennsylvania State University, Hershey 17033.
Gynecol Oncol. 1990 Nov;39(2):132-4. doi: 10.1016/0090-8258(90)90419-l.
To ascertain the clinical significance of hyperkeratosis and parakeratosis in otherwise negative Papanicolaou smears, we retrospectively reviewed 96 patients with these findings seen during a 32-month period. Evaluation included repeating the smear and performing colposcopy in all patients. Colposcopically directed biopsy and endocervical curettage were performed when appropriate. Only one patient had human papillomavirus (HPV) infection. The isolated finding of hyperkeratosis or parakeratosis was not associated with an increased incidence of cervical intraepithelial neoplasia or HPV and, clinically, was not associated with uterine descensus or vaginal prolapse.
为了确定在其他方面巴氏涂片阴性的情况下角化过度和不全角化的临床意义，我们回顾性分析了在32个月期间发现有这些表现的96例患者。评估包括对所有患者重复进行涂片检查和阴道镜检查。必要时进行阴道镜引导下活检和宫颈管刮除术。只有1例患者感染了人乳头瘤病毒（HPV）。孤立的角化过度或不全角化表现与宫颈上皮内瘤变或HPV发病率增加无关，并且在临床上与子宫脱垂或阴道壁脱垂无关。
