Schubert M M, Peterson D E, Flournoy N, Meyers J D, Truelove E L
Fred Hutchinson Cancer Research Center, Seattle, Wash.
Oral Surg Oral Med Oral Pathol. 1990 Sep;70(3):286-93. doi: 10.1016/0030-4220(90)90142-f.
This study analyzed factors associated with acute oropharyngeal herpes simplex virus (HSV) infection in 627 patients who had undergone allogeneic bone marrow transplantation for leukemia, lymphoma, or aplastic anemia. HSV infection developed in 233 (37%) of the patients; all but two were seropositive for HSV before transplant. Sixty-two percent of the seropositive patients had at least one episode of HSV reactivation during the first 100 days after transplant. Other factors that placed patients at increased risk for HSV infection were a pretransplant diagnosis of leukemia, being in remission at the time of transplant, and/or having been conditioned for transplant with chemoradiotherapy. Recognition of factors that may predispose patients to HSV infection helps determine those transplant recipients who might benefit most from antiviral prophylaxis or other approaches to prevention of HSV reactivation.
本研究分析了627例因白血病、淋巴瘤或再生障碍性贫血接受异基因骨髓移植患者中与急性口咽单纯疱疹病毒（HSV）感染相关的因素。233例（37%）患者发生了HSV感染；除2例患者外，其余患者移植前HSV血清学均呈阳性。62%的血清学阳性患者在移植后的前100天内至少有一次HSV再激活发作。使患者发生HSV感染风险增加的其他因素包括移植前诊断为白血病、移植时处于缓解期和/或接受过放化疗预处理以进行移植。识别可能使患者易患HSV感染的因素有助于确定那些可能从抗病毒预防或其他预防HSV再激活的方法中获益最大的移植受者。
