Redding S W, Montgomery M T
Department of General Practice, University of Texas Health Science Center, San Antonio, Texas.
Oral Surg Oral Med Oral Pathol. 1989 Jun;67(6):680-3. doi: 10.1016/0030-4220(89)90008-x.
Reactivation of herpes simplex virus (HSV) appears to play a significant role in oral mucositis resulting from bone marrow transplantation. The acyclic guanosine derivative acyclovir has been shown to be effective in treating and protecting against HSV infection in this group. The purpose of this study was to determine the role of HSV reactivation in oral mucositis in patients undergoing bone marrow transplantation who were seronegative for HSV or who received acyclovir prophylaxis. The results suggest that HSV plays an insignificant role in oral mucositis in these patients.
单纯疱疹病毒（HSV）的再激活似乎在骨髓移植导致的口腔黏膜炎中起重要作用。无环鸟苷衍生物阿昔洛韦已被证明在治疗和预防该组患者的HSV感染方面有效。本研究的目的是确定HSV再激活在接受骨髓移植且HSV血清学阴性或接受阿昔洛韦预防的患者口腔黏膜炎中的作用。结果表明，HSV在这些患者的口腔黏膜炎中起的作用不显著。
