Wade J C, Day L M, Crowley J J, Meyers J D
J Infect Dis. 1984 May;149(5):750-6. doi: 10.1093/infdis/149.5.750.
Herpes simplex virus (HSV) reactivation is common after marrow transplantation, with some patients developing frequent and severe recurrences. Sixty patients were studied to determine both the effect of the specific lymphocyte response to HSV on subsequent recurrences and the effect of acyclovir treatment on restoration of this response. Patients with a positive response after the first HSV recurrence had fewer second recurrences (13 of 28 vs. 18 of 19; P less than .01) and at a longer interval when they did recur (42 vs. 27 days; P less than .0001). Conversely, patients treated with acyclovir had more frequent second recurrences than did those not treated (18 of 21 vs. 13 of 26; P less than .05) and they were at a shorter interval when they did recur (27 vs. 36 days; P = .001). Treated patients also had lower specific lymphocyte responses to HSV. These data confirm the importance of the specific immune response to HSV in the determination of the course of HSV infection after marrow transplant.
单纯疱疹病毒（HSV）再激活在骨髓移植后很常见，一些患者会出现频繁且严重的复发。对60名患者进行了研究，以确定对HSV的特异性淋巴细胞反应对后续复发的影响以及阿昔洛韦治疗对这种反应恢复的影响。首次HSV复发后反应呈阳性的患者第二次复发较少（28例中的13例 vs. 19例中的18例；P小于0.01），且复发时的间隔时间更长（42天 vs. 27天；P小于0.0001）。相反，接受阿昔洛韦治疗的患者第二次复发比未治疗的患者更频繁（21例中的18例 vs. 26例中的13例；P小于0.05），且复发时的间隔时间更短（27天 vs. 36天；P = 0.001）。接受治疗的患者对HSV的特异性淋巴细胞反应也较低。这些数据证实了对HSV的特异性免疫反应在决定骨髓移植后HSV感染病程中的重要性。
