基于结构比对方法测定 Qnr 蛋白中的五肽重复单位。
Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach.
机构信息
Drug Resistance Proteomics Laboratory, Department of Biological Sciences, Myongji University, San 38-2 Namdong, Yongin, Gyeonggido 449-728, Republic of Korea.
出版信息
Antimicrob Agents Chemother. 2011 Sep;55(9):4475-8. doi: 10.1128/AAC.00041-11. Epub 2011 Jun 27.
Abstract
The Qnr proteins belong to the pentapeptide repeat protein family. Despite each pentapeptide repeat unit being an important structural determinant, accurately determining pentapeptide repeat units in the Qnr proteins through sequence-based alignments has been challenging. In the present study, the pentapeptide repeat units of the nine representative Qnr proteins have been precisely determined via the structure-based alignment approach using homology modeling and superposition of their best models.
摘要
Qnr 蛋白属于五肽重复蛋白家族。尽管每个五肽重复单元都是一个重要的结构决定因素，但通过基于序列的比对准确确定 Qnr 蛋白中的五肽重复单元一直具有挑战性。在本研究中，通过使用同源建模和最佳模型的叠加，通过基于结构的比对方法精确确定了 9 种代表性 Qnr 蛋白的五肽重复单元。
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