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MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications.

作者信息

Fernandez-Valverde Selene L, Taft Ryan J, Mattick John S

机构信息

Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.

出版信息

Diabetes. 2011 Jul;60(7):1825-31. doi: 10.2337/db11-0171.

DOI:10.2337/db11-0171
PMID:21709277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3121441/
Abstract
摘要

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JAMA. 2011 Jan 5;305(1):59-67. doi: 10.1001/jama.2010.1919.
2
Genomics, type 2 diabetes, and obesity.基因组学、2型糖尿病与肥胖症
N Engl J Med. 2010 Dec 9;363(24):2339-50. doi: 10.1056/NEJMra0906948.
3
A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis.基于全基因组血清 microRNA 表达谱分析鉴定的五 microRNA 特征可作为胃癌诊断的指纹图谱。
Eur J Cancer. 2011 Mar;47(5):784-91. doi: 10.1016/j.ejca.2010.10.025. Epub 2010 Nov 26.
4
MicroRNA signature of the human developing pancreas.人胰腺发育过程中的 microRNA 特征。
BMC Genomics. 2010 Sep 22;11:509. doi: 10.1186/1471-2164-11-509.
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Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study.血清 microRNAs 在糖尿病前期和新诊断的 2 型糖尿病中的意义:一项临床研究。
Acta Diabetol. 2011 Mar;48(1):61-9. doi: 10.1007/s00592-010-0226-0. Epub 2010 Sep 21.
6
Diabetes mellitus reveals its micro-signature.糖尿病呈现出其微观特征。
Circ Res. 2010 Sep 17;107(6):686-8. doi: 10.1161/CIRCRESAHA.110.228841.
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Perm J. 2010 Fall;14(3):64-72. doi: 10.7812/TPP/09-052.
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J Biol Chem. 2010 Oct 29;285(44):34004-15. doi: 10.1074/jbc.M110.165027. Epub 2010 Aug 16.
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Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1.糖尿病 db/db 小鼠血管平滑肌细胞中 microRNA-125b 水平升高,通过靶向组蛋白甲基转移酶 Suv39h1 导致炎症基因表达增加。
Diabetes. 2010 Nov;59(11):2904-15. doi: 10.2337/db10-0208. Epub 2010 Aug 10.
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FEBS Lett. 2010 Aug 20;584(16):3592-600. doi: 10.1016/j.febslet.2010.07.027. Epub 2010 Jul 24.