Department of Medical Physics and Bioengineering, University College London, London, UK.
Phys Med Biol. 2011 Jul 21;56(14):4333-53. doi: 10.1088/0031-9155/56/14/008. Epub 2011 Jun 27.
We present the results from a feasibility study which measures properties in the terahertz frequency range of excised cancerous, dysplastic and healthy colonic tissues from 30 patients. We compare their absorption and refractive index spectra to identify trends which may enable different tissue types to be distinguished. In addition, we present statistical models based on variations between up to 17 parameters calculated from the reflected time and frequency domain signals of all the measured tissues. These models produce a sensitivity of 82% and a specificity of 77% in distinguishing between healthy and all diseased tissues and a sensitivity of 89% and a specificity of 71% in distinguishing between dysplastic and healthy tissues. The contrast between the tissue types was supported by histological staining studies which showed an increased vascularity in regions of increased terahertz absorption.
我们展示了一项可行性研究的结果，该研究测量了来自 30 名患者的切除的癌变、发育不良和健康结肠组织在太赫兹频率范围内的特性。我们比较了它们的吸收和折射率谱，以确定可能使不同组织类型得以区分的趋势。此外，我们还提出了基于从所有测量组织的反射时域和频域信号中计算出的多达 17 个参数之间变化的统计模型。这些模型在区分健康组织和所有病变组织时的灵敏度为 82%，特异性为 77%，在区分发育不良组织和健康组织时的灵敏度为 89%，特异性为 71%。组织类型之间的对比度得到了组织学染色研究的支持，该研究表明，在太赫兹吸收增加的区域，血管生成增加。
