The Myc-ARF-Egr1 pathway: unleashing the apoptotic power of c-Myc.
作者信息
Boone David N, Hann Stephen R
出版信息
Cell Cycle. 2011 Jul 1;10(13):2043-4. doi: 10.4161/cc.10.13.15711.
Abstract
摘要
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本文引用的文献
1
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.Egr1 通过一种非典型的 ARF 依赖性转录机制介导 p53 非依赖性 c-Myc 诱导的细胞凋亡。
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):632-7. doi: 10.1073/pnas.1008848108. Epub 2010 Dec 27.
2
Regulatory interdependence of myeloid transcription factors revealed by Matrix RNAi analysis.基质 RNAi 分析揭示了髓系转录因子的调控相互依赖关系。
Genome Biol. 2009;10(11):R121. doi: 10.1186/gb-2009-10-11-r121. Epub 2009 Nov 2.
3
The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.转录因子Egr1和Egr2对脂肪细胞分化具有相反的影响。
Cell Death Differ. 2009 May;16(5):782-9. doi: 10.1038/cdd.2009.11. Epub 2009 Feb 20.
4
Distinct thresholds govern Myc's biological output in vivo.不同的阈值在体内调控Myc的生物学效应。
Cancer Cell. 2008 Dec 9;14(6):447-57. doi: 10.1016/j.ccr.2008.10.018.
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Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation.核磷蛋白直接与c-Myc相互作用，并控制c-Myc诱导的过度增殖和转化。
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Concurrent down-regulation of Egr-1 and gelsolin in the majority of human breast cancer cells.在大多数人类乳腺癌细胞中Egr-1和凝溶胶蛋白的同时下调。
Cancer Genomics Proteomics. 2007 Nov-Dec;4(6):377-85.
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