Meyer Natalie, Kim Sam S, Penn Linda Z
Division of Cancer Genomics and Proteomics, Ontario Cancer Institute/Princess Margaret Hospital, Department of Medical Biophysics, University of Toronto, Toronto, Ont, Canada.
Semin Cancer Biol. 2006 Aug;16(4):275-87. doi: 10.1016/j.semcancer.2006.07.011. Epub 2006 Jul 14.
The discovery that the Myc oncoprotein could drive cells to undergo apoptosis in addition to its well-established role in cellular proliferation came in the early 1990s, at the beginning of a period of explosive research on cell death. Experimental evidence revealed that Myc sensitises cells to a wide range of death stimuli and abrogating this biological activity plays a profound role in tumorigenesis. Our understanding of the molecular mechanism and genetic programme of Myc-induced apoptosis remains shrouded in mystery and the focus of much attention. In this review, we will discuss established data, recent advances and future objectives regarding the regulatory processes and the functional cooperators that effect and abrogate apoptosis induced by Myc.
20世纪90年代初，在对细胞死亡进行爆炸性研究的初期，人们发现Myc癌蛋白除了在细胞增殖中已确立的作用外，还能驱动细胞发生凋亡。实验证据表明，Myc使细胞对多种死亡刺激敏感，而消除这种生物学活性在肿瘤发生中起着重要作用。我们对Myc诱导凋亡的分子机制和遗传程序的理解仍然笼罩在神秘之中，也是备受关注的焦点。在这篇综述中，我们将讨论关于调控过程以及影响和消除Myc诱导凋亡的功能协同因子的既定数据、最新进展和未来目标。
