Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, PR China.
J Cardiovasc Med (Hagerstown). 2011 Sep;12(9):648-52. doi: 10.2459/JCM.0b013e328349424b.
Some studies have reported that the HLA-DRB1 allele was associated with idiopathic dilated cardiomyopathy. However, there have been inconsistent results among different studies. To clarify the association of HLA-DRB1 and idiopathic dilated cardiomyopathy, a meta-analysis of case-control studies was performed.
PubMed database, Science Citation Index database, The Cochrane Central Register of Controlled Trials database, China National Knowledge Information database, Chinese Biomedical Literature database, Wanfang database, and VIP database in China were searched. Search terms included dilated cardiomyopathy and DRB1. Five case-control studies were included in the present meta-analysis to assess the association between HLA-DRB11401, HLA-DRB10901, HLA-DRB1*0301, and idiopathic dilated cardiomyopathy.
A total of four studies were included in our meta-analysis for HLA-DRB11401 and HLA-DRB10901. The pooled odds ratio (OR) was 2.6 [95% confidence interval (CI) 1.11-6.11, P<0.05] and 0.70 (95% CI 0.48-1.00, P=0.05), respectively. For the HLA-DRB10301 allele, just three studies were included in our meta-analysis. The pooled OR was 0.49 (95% CI 0.27-0.91, P<0.05). The present meta-analysis indicated that the frequency of HLA-DRB11401 was higher in idiopathic dilated cardiomyopathy patients than in healthy people, whereas HLA-DRB10901 and HLA-DRB10301 were higher in healthy people than in idiopathic dilated cardiomyopathy patients.
The HLA-DRB11401 allele might be a risk factor for idiopathic dilated cardiomyopathy and HLA-DRB10901 and HLA-DRB1*0301 might protect humans from idiopathic dilated cardiomyopathy.
一些研究报道 HLA-DRB1 等位基因与特发性扩张型心肌病有关。然而，不同研究之间的结果并不一致。为了阐明 HLA-DRB1 与特发性扩张型心肌病的关系，进行了病例对照研究的荟萃分析。
检索 PubMed 数据库、科学引文索引数据库、The Cochrane Central Register of Controlled Trials 数据库、中国国家知识信息数据库、中国生物医学文献数据库、万方数据库和中国 VIP 数据库。检索词包括扩张型心肌病和 DRB1。本荟萃分析纳入了 5 项病例对照研究，以评估 HLA-DRB11401、HLA-DRB10901、HLA-DRB1*0301 与特发性扩张型心肌病之间的关系。
共有 4 项研究纳入本荟萃分析评估 HLA-DRB11401 和 HLA-DRB10901。合并的优势比（OR）分别为 2.6[95%置信区间（CI）1.11-6.11，P<0.05]和 0.70（95% CI 0.48-1.00，P=0.05）。对于 HLA-DRB10301 等位基因，仅 3 项研究纳入本荟萃分析。合并的 OR 为 0.49（95% CI 0.27-0.91，P<0.05）。本荟萃分析表明，特发性扩张型心肌病患者 HLA-DRB11401 频率高于健康人，而 HLA-DRB10901 和 HLA-DRB10301 频率则相反。
HLA-DRB11401 等位基因可能是特发性扩张型心肌病的危险因素，而 HLA-DRB10901 和 HLA-DRB1*0301 可能使人类免受特发性扩张型心肌病的影响。
