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本文引用的文献

1
Hashimoto's encephalopathy: a case report with neuropsychological testing.
Gen Hosp Psychiatry. 2007 May-Jun;29(3):267-9. doi: 10.1016/j.genhosppsych.2007.01.003.
2
High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy.桥本脑病中针对α-烯醇化酶氨基末端的血清自身抗体高流行率。
J Neuroimmunol. 2007 Apr;185(1-2):195-200. doi: 10.1016/j.jneuroim.2007.01.018. Epub 2007 Mar 1.
3
The neurological disorder associated with thyroid autoimmunity.与甲状腺自身免疫相关的神经疾病。
J Neurol. 2006 Aug;253(8):975-84. doi: 10.1007/s00415-006-0170-7. Epub 2006 Jun 19.
4
Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy.抗α-烯醇化酶氨基末端的自身抗体是桥本脑病的一种有用诊断标志物。
J Neuroimmunol. 2005 May;162(1-2):130-6. doi: 10.1016/j.jneuroim.2005.02.004.
5
Hashimoto's encephalopathy: myth or reality? An endocrinologist's perspective.桥本脑病：虚构还是真实？一位内分泌学家的观点。
Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):53-66. doi: 10.1016/j.beem.2004.11.006.
6
Thyroid peroxidase autoantibodies in euthyroid subjects.甲状腺功能正常者体内的甲状腺过氧化物酶自身抗体
Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):1-15. doi: 10.1016/j.beem.2004.11.003.
7
Hashimoto's encephalopathy: steroid resistance and response to intravenous immunoglobulins.桥本脑病：类固醇抵抗及对静脉注射免疫球蛋白的反应
J Neurol Neurosurg Psychiatry. 2005 Mar;76(3):455-6. doi: 10.1136/jnnp.2004.049395.
8
Hashimoto's encephalopathy: epidemiologic data and pathogenetic considerations.桥本脑病：流行病学数据及发病机制探讨
J Neurol Sci. 2004 Feb 15;217(2):165-8. doi: 10.1016/j.jns.2003.09.007.
9
Hashimoto encephalopathy: syndrome or myth?桥本脑病：综合征还是虚构之事？
Arch Neurol. 2003 Feb;60(2):164-71. doi: 10.1001/archneur.60.2.164.
10
Encephalopathy associated with Hashimoto thyroiditis: diagnosis and treatment.桥本甲状腺炎相关脑病：诊断与治疗
J Neurol. 1996 Aug;243(8):585-93. doi: 10.1007/BF00900946.

一名患有格雷夫斯病的马来女性的桥本脑病病例。

A case of Hashimoto encephalopathy in a Malay woman with Graves disease.

作者信息

Ngiu Chai Soon, Ibrahim Norlinah M, Yahya Wan Nur Nafisah Wan, Tan Hui Jan, Mustafa Norlaila, Basri Hamidon, Ali Raymond Azman

机构信息

Hospital UKM, Department of Medicine, Jalan Yaacob Latiff, Kuala Lumpur, 56000, Malaysia.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.01.2009.1501. Epub 2009 Jun 26.

DOI:10.1136/bcr.01.2009.1501
PMID:21709844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3027930/
Abstract

Hashimoto encephalopathy (HE) is a poorly recognised steroid-responsive encephalopathy, with prominent neuropsychiatric features. Diagnosis is often difficult due to its heterogeneous clinical presentation, especially since the thyroid status or anti-thyroid antibody titres may not be related to the disease state. Here, the case of a 23-year-old Malay woman with Graves disease who presented with progressive encephalopathy diagnosed as HE is presented. She responded dramatically to high dose intravenous and then oral corticosteroid. A month after the initiation of treatment, she regained full independency.

摘要

桥本脑病（HE）是一种认识不足的类固醇反应性脑病，具有突出的神经精神症状。由于其临床表现多样，诊断往往困难，特别是因为甲状腺状态或抗甲状腺抗体滴度可能与疾病状态无关。本文报告了一例23岁患有格雷夫斯病的马来女性，她因进行性脑病被诊断为HE。她对大剂量静脉注射然后口服皮质类固醇有显著反应。治疗开始一个月后，她恢复了完全独立。