幽门螺杆菌对远端胃癌的生存率没有影响。

Helicobacter pylori has no influence on distal gastric cancer survival.

作者信息

Santos Renata S, Lourenço José E V, Herbella Fernando Augusto Mardiros, Del Grande Jose Carlos, Patti Marco G

机构信息

Department of Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.

出版信息

Arq Gastroenterol. 2011 Apr-Jun;48(2):109-11. doi: 10.1590/s0004-28032011000200005.

DOI:10.1590/s0004-28032011000200005

PMID:21709951

Abstract

CONTEXT

There is some evidence that Helicobacter pylori correlates with distal gastric cancer genesis. However, few studies analyzed the survival related to H. pylori infection.

OBJECTIVE

To correlate gastric cancer survival and H. pylori infection.

METHODS

Sixty-eight patients with distal gastric cancer that underwent subtotal gastrectomy were studied. Minimal follow-up was 1 month. H. pylori infection was confirmed by biopsy.

RESULTS

Thirty-four patients (19 males (55.9%), mean age 60.9 ± 14.03, range 33-82 years) were H. pylori positive. Thirty-four patients (16 males (47.1%), mean age 57.9 ± 13.97, range 27-85 years) were H. pylori negative. Groups were comparable in regards to age (P = 0.4), gender (P = 0.5), stage [T (P = 0.2), N (P = 0.6) and M (P = 0.9)]. Survival was not different when groups were compared [P = 0.1616 (hazard ratio 0.6834, 95% CI 0.4009 to 1.1647)].

CONCLUSIONS

H. pylori infection does not affect distal gastric cancer survival.

摘要

背景

有证据表明幽门螺杆菌与远端胃癌的发生有关。然而，很少有研究分析与幽门螺杆菌感染相关的生存率。

目的

研究胃癌生存率与幽门螺杆菌感染之间的关系。

方法

对68例行远端胃癌次全切除术的患者进行研究。最短随访时间为1个月。通过活检确诊幽门螺杆菌感染。

结果

34例患者（19例男性（55.9%），平均年龄60.9±14.03岁，范围33 - 82岁）幽门螺杆菌呈阳性。34例患者（16例男性（47.1%），平均年龄57.9±13.97岁，范围27 - 85岁）幽门螺杆菌呈阴性。两组在年龄（P = 0.4）、性别（P = 0.5）、分期[T（P = 0.2）、N（P = 0.6）和M（P = 0.9）]方面具有可比性。比较两组时生存率无差异[P = 0.1616（风险比0.6834，95%置信区间0.4009至1.1647）]。