Department of Psychology, Faculty of Human Sciences, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554, Japan.
J Physiol Sci. 2011 Sep;61(5):421-7. doi: 10.1007/s12576-011-0159-6. Epub 2011 Jun 28.
Bilobalide, a unique constituent of Ginkgo biloba, has been reported to potentiate population spikes in hippocampal CA1 pyramidal cells and to protect the brain against cell death. In this study, the effects of bilobalide on synaptic transmission and its plasticity in rat hippocampal subfields were electrophysiologically investigated. Bilobalide (50 μM) significantly potentiated the input-output relationship at Schaffer collateral (SC)-CA1 synapses but not at medial perforant path (MPP)-dentate gyrus (DG), lateral perforant path (LPP)-DG, or mossy fiber (MF)-CA3 synapses. Facilitative effects of bilobalide on synaptic plasticity were only observed at MPP-DG synapses, in which the induction of long-term depression was blocked in the presence of bilobalide. However, no effect on synaptic plasticity was observed at SC-CA1 synapses. These results suggest that bilobalide has differential effects on synaptic efficacy in each hippocampal subfield.
银杏内酯 B，一种独特的银杏叶成分，已被报道能增强海马 CA1 锥体神经元的群体峰电位，并保护大脑免受细胞死亡。在这项研究中，通过电生理学方法研究了银杏内酯 B 对大鼠海马亚区突触传递及其可塑性的影响。银杏内酯 B（50μM）显著增强了 Schaffer 侧支（SC）-CA1 突触的输入-输出关系，但对内侧穿通路径（MPP）-齿状回（DG）、外侧穿通路径（LPP）-DG 或苔藓纤维（MF）-CA3 突触没有影响。银杏内酯 B 仅在 MPP-DG 突触上表现出促进突触可塑性的作用，在银杏内酯 B 存在的情况下，长时程抑制的诱导被阻断。然而，在 SC-CA1 突触上没有观察到对突触可塑性的影响。这些结果表明，银杏内酯 B 对每个海马亚区的突触效能有不同的影响。
