Galluzzo Maria Laura, Garcia de Davila Maria T, Vujanić Gordan M
Department of Pathology, Hospital Nacional de Pediatría JP Garrahan, Buenos Aires, Argentina.
Pediatr Dev Pathol. 2012 Jan-Feb;15(1):65-70. doi: 10.2350/11-03-1007-CR.1. Epub 2011 Jun 28.
A coexistence of different renal tumors has rarely been reported. The most commonly described association is of Wilms tumor and renal cell carcinoma. Metanephric adenofibroma has also been associated with Wilms tumor or papillary renal cell carcinoma. Another reported association is metanephric adenoma and papillary renal cell carcinoma with sarcomatoid dedifferentiation. Herein we describe a complex renal tumor containing areas of metanephric adenofibroma, Wilms tumor, and undifferentiated renal cell carcinoma in a previously healthy 18-year-old boy. The tumor showed histologic and immunohistochemical features of these 3 different tumors, offering additional support to the view that these 3 tumors are related.
不同肾肿瘤并存的情况鲜有报道。最常描述的关联是肾母细胞瘤与肾细胞癌。后肾腺纤维瘤也与肾母细胞瘤或乳头状肾细胞癌有关。另一个报道的关联是后肾腺瘤与伴有肉瘤样去分化的乳头状肾细胞癌。在此，我们描述了一名既往健康的18岁男孩，其患有一种复杂的肾肿瘤，包含后肾腺纤维瘤、肾母细胞瘤和未分化肾细胞癌区域。该肿瘤显示出这3种不同肿瘤的组织学和免疫组化特征，为这3种肿瘤相关的观点提供了更多支持。
