肾细胞癌病例，曾成功治疗过肾母细胞瘤。

A case of renal cell carcinoma after successful treatment of Wilms tumor.

机构信息

Department of Surgery, Pediatric Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

出版信息

J Pediatr Surg. 2010 Sep;45(9):1883-6. doi: 10.1016/j.jpedsurg.2010.06.032.

DOI:10.1016/j.jpedsurg.2010.06.032

PMID:20850637

Abstract

This case report documents the eighth reported case of renal cell carcinoma (RCC) occurring after treatment of Wilms tumor. Although secondary malignancies after treatment of Wilms tumors are not infrequent, RCC as the second malignancy is rare. We discuss a 17-year-old girl whose RCC was diagnosed 12.5 years after diagnosis of a Wilms tumor. In addition, we review the literature on the subject. Renal cell carcinoma has been proposed as a consequent of chemoradiation; however, a genetic susceptibility must be considered. Because it is routine to assess the functional status of the remaining solitary kidney by annual ultrasonography, we recommend assessing for the presence of secondary renal malignancies and perhaps continuing routine ultrasounds long-term.

摘要

本病例报告记录了第八例在治疗肾母细胞瘤（Wilms 瘤）后发生的肾细胞癌（RCC）。虽然 Wilms 瘤治疗后的继发性恶性肿瘤并不少见，但 RCC 作为第二种恶性肿瘤则较为罕见。我们讨论了一名 17 岁女孩的病例，其 RCC 在诊断 Wilms 瘤 12.5 年后被诊断出。此外，我们还回顾了该主题的文献。已经提出 RCC 是化疗和放疗的结果；然而，必须考虑遗传易感性。由于常规做法是通过每年的超声检查来评估剩余孤立肾脏的功能状态，因此我们建议评估是否存在继发性肾脏恶性肿瘤，并可能长期进行常规超声检查。