School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Eur J Med Chem. 2011 Sep;46(9):3788-94. doi: 10.1016/j.ejmech.2011.05.044. Epub 2011 Jun 7.
Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, (1)H NMR, (13)C NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a-d and 15a-h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains.
已经合成了两个新的系列的肼基噻唑基香豆素衍生物，并通过红外光谱（IR）、（1）H NMR、（13）C NMR、元素分析和质谱数据进行了全面表征。一些化合物的结构还通过 X 射线晶体学进一步确认。所有这些衍生物，10a-d 和 15a-h，都在体外进行了抗微生物活性筛选，针对包括结核分枝杆菌和白色念珠菌在内的各种细菌。化合物 10c、10d 和 15e 对所有测试的微生物菌株都表现出非常好的活性。
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