3-（溴乙酰基）香豆素：解析其合成、化学性质及应用

3-(Bromoacetyl)coumarins: unraveling their synthesis, chemistry, and applications.

作者信息

Abdou Moaz M, Abu-Rayyan Ahmed, Bedir Ahmed G, Abdel-Fattah S, Omar A M A, Ahmed Abdullah A, El-Desoky El-Sayed I, Ghaith Eslam A

机构信息

Egyptian Petroleum Research Institute Nasr City Cairo 11727 Egypt

Faculty of Science, Applied Science Private University P. O. BOX 166 Amman 11931 Jordan.

出版信息

RSC Adv. 2021 Nov 29;11(61):38391-38433. doi: 10.1039/d1ra05574g.

DOI:10.1039/d1ra05574g

PMID:35493203

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9044231/

Abstract

This review emphasizes recent developments in synthetic routes of 3-(bromoacetyl)coumarin derivatives. Also, chemical reactions of 3-(bromoacetyl)coumarins as versatile building blocks in the preparation of critical polyfunctionalized heterocyclic systems and other industrially significant scaffolds are described. Recent advances of 3-(bromoacetyl)coumarins as attractive starting points towards a wide scale of five and six-membered heterocyclic systems such as thiophenes, imidazoles, pyrazoles, thiazoles, triazoles, pyrans, pyridines, thiadiazins as well as fused heterocyclic systems have been reported. Additionally, this review covers a wide range of analytical chemistry, fluorescent sensors, and biological applications of these moieties, covering the literature till May 2021.

摘要

本综述重点介绍了3-(溴乙酰基)香豆素衍生物合成路线的最新进展。此外，还描述了3-(溴乙酰基)香豆素作为通用构建块在制备关键多官能化杂环体系和其他具有工业意义的支架中的化学反应。据报道，3-(溴乙酰基)香豆素作为合成多种五元及六元杂环体系（如噻吩、咪唑、吡唑、噻唑、三唑、吡喃、吡啶、噻二嗪）以及稠合杂环体系的有吸引力的起始原料，取得了最新进展。此外，本综述涵盖了这些部分在分析化学、荧光传感器及生物学方面的广泛应用，文献涵盖至2021年5月。