Antibacterial Activity for Synthesized Coumarin Derivatives and a Coumarin Component of Lime Peel ().

In this study, we investigated the antibacterial activity of the coumarin component isolated from lime peel and coumarin derivatives synthesized using various techniques against eight types of food-poisoning bacteria. The minimum inhibitory concentration (MIC) for the [5,7-dihydroxy-4-trifluoromethylcoumarin] derivative was measured as 1.5 mM in and subsp. ; that for the [7-hydroxy-4-trifluoromethylcoumarin] derivative was 1.7 mM in ; and that for the [dicoumarol] derivative was 1.2 mM in . These results confirmed that coumarin derivatives with CF and OH substituents had enhanced antibacterial activity.