Kiuchi Y
Dept. of Ophthalmol., Hiroshima Univ. School of Med., Japan.
Nippon Ganka Gakkai Zasshi. 1990 Jul;94(7):663-72.
Griseolic acid-ester (GA-ester), one of the strongest cAMP phosphodiesterase inhibitors, was combined with isoproterenol and timolol in this study to evaluate the effect on intraocular pressure (IOP). Furthermore, the ocular hypotensive effect of GA-ester in pigmented and albino rabbits was compared, and the binding ability of GA-ester to synthetic melanin was examined. GA-ester markedly enhanced the hypotensive effect of isoproterenol, and the combination of GA-ester with timolol resulted in an additional fall in IOP. No differences in the hypotensive effect of GA-ester between pigmented and albino rabbits were observed. GA-ester did not bind to synthetic melanin. GA-ester has unique characteristics as an ocular hypotensive agent.
灰黄霉素酸酯（GA-酯）是最强的环磷酸腺苷磷酸二酯酶抑制剂之一，本研究将其与异丙肾上腺素和噻吗洛尔联合使用，以评估对眼压（IOP）的影响。此外，比较了GA-酯在有色兔和白化兔中的降眼压作用，并检测了GA-酯与合成黑色素的结合能力。GA-酯显著增强了异丙肾上腺素的降压作用，GA-酯与噻吗洛尔联合使用导致眼压进一步下降。未观察到GA-酯在有色兔和白化兔中的降压作用有差异。GA-酯不与合成黑色素结合。GA-酯作为一种降眼压药物具有独特的特性。
